ANTIIDIOTYPIC ANTIBODIES SPECIFIC FOR HLA IN HEART AND KIDNEY ALLOGRAFT RECIPIENTS

被引：10

作者：

REED, E

HO, E

COHEN, DJ

RAMEY, W

MARBOE, C

DAGATI, V

ROSE, EA

HARDY, M

SUCIUFOCA, N

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG, DEPT PATHOL, 630 W 168TH ST, NEW YORK, NY 10032 USA

[2] COLUMBIA UNIV COLL PHYS & SURG, DEPT MED, NEW YORK, NY 10032 USA

[3] COLUMBIA UNIV COLL PHYS & SURG, DEPT SURG, NEW YORK, NY 10032 USA

[4] UNIV COLUMBIA, ST LUKES ROOSEVELT HOSP, COLL PHYSICIANS & SURGEONS, DEPT SURG, NEW YORK, NY USA

来源：

IMMUNOLOGIC RESEARCH | 1993年 / 12卷 / 01期

关键词：

ANTIIDIOTYPIC ANTIBODIES; ANTI-HLA ANTIBODIES; IR GENE CONTROL; HEART TRANSPLANTATION; KIDNEY TRANSPLANTATION;

D O I：

10.1007/BF02918364

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic rejection is the major threat to both heart and renal allograft survival. We have explored the possibility that some patients with anti-donor HLA antibodies (Ab1) develop specific anti-idiotypic antibodies (Ab2) which suppress the production of Ab1, and subsequently, the progression of chronic rejection. Analysis of Ab2 in sera obtained from Ab1 producers showed that 22% of heart and 18% of kidney recipients produced Ab2. The 4- and 5-year actuarial graft survivals in Ab2 producers were 100% and 83%, respectively, compared to 57% in patients who formed Ab1 but not Ab2 (p < 0.004). Patients carrying the DR2 alleles, DRB1 *1501, *1502 or *1601 were at a lower risk of producing anti-donor HLA antibodies.

引用

页码：1 / 11

页数：11

共 50 条

[41] Prevalence of Iron Deficiency in Heart and Kidney Allograft Recipients
Przybylowski, P.
Malyszko, J.
Glowinska, I.
Malyszko, J.
Kozlowska, S.
Mysliwiec, M.
TRANSPLANTATION PROCEEDINGS, 2011, 43 (10) : 3885 - 3887
[42] Hemojuvelin and Iron Metabolism in Kidney and Heart Allograft Recipients
Przybylowski, P.
Koc-Zorawska, E.
Glowinska, I.
Levin-Iaina, N.
Macdougall, I. C.
Malyszko, J. S.
Mysliwiec, M.
Malyszko, J.
TRANSPLANTATION PROCEEDINGS, 2013, 45 (01) : 391 - 393
[43] Anemia in Heart and Kidney Allograft Recipients: Is There a Role for Hepcidin?
Przybylowski, P.
Malyszko, J.
Malyszko, J. S.
Koc-Zorawska, E.
Sadowski, J.
Mysliwiec, M.
TRANSPLANTATION PROCEEDINGS, 2010, 42 (10) : 4255 - 4258
[44] ANALYSIS OF HLA ANTIBODIES AFTER NATIVE NEPHRECTOMY IN RENAL ALLOGRAFT RECIPIENTS
Boole, Benita K.
Wiebke, Eric A.
Taber, Tim
Higgins, Nancy
Goggins, William
Mujtaba, Muhammad A.
Sharfuddin, Asif
HUMAN IMMUNOLOGY, 2018, 79 : 144 - 144
[45] Sex-Specific Differences in HLA Antibodies after Pneumococcal Vaccination in Kidney Transplant Recipients
Lindemann, Monika
Oesterreich, Simon
Wilde, Benjamin
Eisenberger, Ute
Muelling, Nils
Horn, Peter A.
Heinemann, Falko M.
Witzke, Oliver
VACCINES, 2019, 7 (03)
[46] RELATION OF HLA ANTIBODIES AND GRAFT ATHEROSCLEROSIS IN HUMAN CARDIAC ALLOGRAFT RECIPIENTS
ROSE, EA
PEPINO, P
BARR, ML
SMITH, CR
RATNER, AJ
HO, E
BERGER, C
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 1992, 11 (03): : S120 - S123
[47] ASSESSMENT OF DONOR SPECIFIC HLA ANTIBODIES IN KIDNEY RECIPIENTS TREATED WITH RITUXIMAB: 11 CASE REPORTS
Khoy, Kathy
Dauny, Francoise
Bardy, Beatrice
Malvezzi, Paolo
Masson, Dominique
TISSUE ANTIGENS, 2012, 79 (06): : 492 - 492
[48] STRONG ASSOCIATION BETWEEN THE PRESENCE OF DONOR SPECIFIC MICROCHIMERISM AND DONOR SPECIFIC HLA ANTIBODIES IN KIDNEY TRANSPLANT RECIPIENTS
Yonemoto, Sayoko
Kishikawa, Hidefumi
Yoshida, Yasuyuki
Aoki, Katsunori
Ueda, Norichika
Okuno, Ayako
Fujii, Naohiko
Hirai, Toshiaki
Nishimura, Kenji
Kinoshita, Tomoko
Hashimoto, Mitsuo
Ichikawa, Yasuji
TRANSPLANT INTERNATIONAL, 2013, 26 : 38 - 38
[49] COLD AND WARM ANTIBODIES AND GRAFT SURVIVAL IN KIDNEY ALLOGRAFT RECIPIENTS
KLOUDA, PT
JEANNET, M
LANCET, 1976, 1 (7965): : 876 - 878
[50] HLA CLASS II REACTIVE SERA FROM KIDNEY ALLOGRAFT RECIPIENTS: DETECTION OF ANTIBODIES SPECIFIC FOR EPITOPES OF DQ AND DP ALPHA/BETA CHAINS.
Piazza, Antonina
Poggi, Elvira
Ozzella, Giuseppina
Imbroglini, Valentina
Caputo, Daniela
Cremona, Rosa
Adorno, Domenico
HUMAN IMMUNOLOGY, 2010, 71 : S135 - S135

← 1 2 3 4 5 →