COMPARISON OF VARIOUS HYPHENATED CHROMATOGRAPHY - MASS-SPECTROMETRY METHODS FOR THE ANALYSIS OF BETA-AGONISTS

Different chromatography - mass spectrometry techniques for the analysis of beta-agonists have been compared. Gas chromatography - mass spectrometry (electron impact) has been used, as also has liquid chromatography coupled to the mass spectrometer by either thermospray or electrospray interfaces. The results obtained by the three method were compared in terms of sensitivity, selectivity, and richness of information provided by the analysis. It was found that using electrospray ionization, very powerful analysis could be achieved with high sensitivity, thus providing significant potential for the analysis of beta-agonists.