STEREOCHEMISTRY AND DYNAMICS OF THE INCLUSION COMPLEX OF (S)-(+)-FENOPROFEN WITH CYCLOMALTOHEPTAOSE (BETA-CYCLODEXTRIN)

被引：23
|
作者：
UCCELLOBARRETTA, G [1 ]
CHIAVACCI, C [1 ]
BERTUCCI, C [1 ]
SALVADORI, P [1 ]
机构：
[1] CNR,DIPARTIMENTO CHIM & CHIM IND,CTR STUDIO MACROMOLEC STEREORDINATE & OTTICAMENTE ATT,I-56126 PISA,ITALY
来源：
CARBOHYDRATE RESEARCH | 1993年 / 243卷 / 01期
关键词：
D O I：
10.1016/0008-6215(93)84077-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The inclusion complex of the calcium salt of (S)-2-(3-phenoxyphenyl)propionic acid with cyclomaltoheptaose (beta-cyclodextrin) was investigated by H-1 NMR spectroscopy. The stoichiometry of the complex was determined by the continous variation method and the association constant by the Benesi-Hildebrand procedure. Measurements of proton selective relaxation rates allowed the dynamics of the complex to be investigated and the determination of intermolecular H-1{H-1}-NOE enhancements revealed the stereochemistry in solution.
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页码：1 / 10
页数：10
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