THE ATYPICAL ANTIPSYCHOTIC DRUG AMPEROZIDE ENHANCES RAT CORTICAL AND STRIATAL DOPAMINE EFFLUX

被引：38
|
作者：
PEHEK, EA [1 ]
MELTZER, HY [1 ]
YAMAMOTO, BK [1 ]
机构：
[1] CASE WESTERN RESERVE UNIV, SCH MED, DEPT PSYCHIAT, CLEVELAND, OH 44106 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 240卷 / 01期
关键词：
PREFRONTAL CORTEX; MICRODIALYSIS; DOPAMINE; SCHIZOPHRENIA; AMPEROZIDE; CLOZAPINE;
D O I：
10.1016/0014-2999(93)90555-V
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Previous behavioral, biochemical, and electrophysiological studies have indicated that amperozide, a putative atypical antipsychotic drug with potent 5-HT2 receptor antagonist potency, preferentially affects mesocorticolimbic, as compared to mesostriatal dopamine neurons. The present experiment utilized in vivo microdialysis to compare the effects of amperozide on dopamine efflux in medial prefrontal cortex versus caudate-putamen in the freely moving rat. The results demonstrated that amperozide produced a greater elevation of cortical dopamine. These results were similar to those observed with clozapine but not haloperidol.
引用
收藏
页码：107 / 109
页数：3
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