INFLUENZA-VIRUS NEURAMINIDASE - STRUCTURE, ANTIBODIES, AND INHIBITORS

被引：273

作者：

COLMAN, PM

机构：

[1] Biomolecular Research Institute, Parkville, Victoria, 3052

来源：

PROTEIN SCIENCE | 1994年 / 3卷 / 10期

关键词：

ANTIGEN-ANTIBODY INTERACTIONS; ANTIGENIC VARIATION; DRUG DESIGN; ENZYME INHIBITION;

D O I：

10.1002/pro.5560031007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The determination of the 3-dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti-influenza virus drug.

引用

页码：1687 / 1696

页数：10

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