INTERACTIONS OF 5-HYDROXYTRYPTAMINE WITH OXIDATIVE-ENZYMES

被引：62
|
作者：
WRONA, MZ [1 ]
DRYHURST, G [1 ]
机构：
[1] UNIV OKLAHOMA,DEPT CHEM & BIOCHEM,NORMAN,OK 73019
来源：
BIOCHEMICAL PHARMACOLOGY | 1991年 / 41卷 / 08期
关键词：
D O I：
10.1016/0006-2952(91)90653-M
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Peroxidase (EC 1.11.1.7)/H2O2, ceruloplasmin (human type X)/O2, and tyrosinase (EC 1.14.18.1)/O2 all oxidized the indolic neurotransmitter 5-hydroxytryptamine (5-HT) in the physiological pH domain. Peroxidase/H2O2 oxidized 5-HT at pH values down to about 2.5. All oxidation reactions generated complex mixtures of products which included at least one known neurotoxin, tryptamine-4,5-dione. In general, the enzymatic oxidation pathways paralleled the in vitro electrochemical oxidation of 5-HT which has permitted suggestions to be made concerning the probable mechanisms of the enzyme-mediated reactions.
引用
收藏
页码：1145 / 1162
页数：18
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