SYNTHESIS OF ALPHA,BETA-UNSATURATED SPIROLACTAMS BY INTRAMOLECULAR CYCLIZATION OF ENDOCYCLIC N-ACYLIMINIUM IONS

被引：11

作者：

MARTIN, MJ ^{[1
]}

BERMEJO, F ^{[1
]}

机构：

[1] UNIV SALAMANCA,FAC QUIM,DEPT QUIM ORGAN,E-37008 SALAMANCA,SPAIN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 42期

关键词：

D O I：

10.1016/0040-4039(95)01568-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of (+/-)-6-benzyl-3-methyl-3-en-1,6-diazaspiro-[4.5]decane-2,7-dione (18), the spiro moiety of (+/-)-pandamarine has been achieved try oxidative cyclization of the (Z) and (E) isomers of 5-(N-benzyl-4-carboxamido-butylidene)-3-methyl-3-en-pyrrolin-2-one (15a) and(15b). The stereoselectivity exhibited in the intramolecular cyclization by both butylidene precursors has also been discussed.

引用

页码：7705 / 7708

页数：4

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