CHARACTERIZATION OF CARBOHYDRATES IN THE ALPHA-2-MACROGLOBULIN RECEPTOR

被引：10
|
作者：
JENSEN, PH [1 ]
GLIEMANN, J [1 ]
ORNTOFT, T [1 ]
机构：
[1] AARHUS UNIV HOSP,DEPT CLIN CHEM,DK-8000 AARHUS,DENMARK
来源：
FEBS LETTERS | 1992年 / 305卷 / 02期
关键词：
ALPHA-2-MACROGLOBULIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; GLYCOSYLATION; LECTIN;
D O I：
10.1016/0014-5793(92)80879-L
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Carbohydrates were characterized in the human placental alpha-2-macroglobulin receptor and its associated protein. Carbohydrates, largely N-linked, contributed to about 18% of the size of the receptor alpha-chain and to about 25% of the beta-chain. The 40 kDa receptor-associated protein also contained carbohydrate. The alpha- and beta-chains contained a wide variety of carbohydrates as judged by binding of lectins. Monosaccharide-competing inhibition of alpha-2M-methylamine binding by WGA suggested a functional significance of sugars in binding of ligands to the alpha-chain.
引用
收藏
页码：129 / 132
页数：4
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