CIMETIDINE DOES NOT ALTER SPARFLOXACIN PHARMACOKINETICS

被引：0
|
作者：
GRIES, JM
HONORATO, J
TABURET, AM
ALVAREZ, MP
SADABA, B
AZANZA, JR
SINGLAS, E
机构：
[1] UNIV NAVARRA,E-31080 PAMPLONA,SPAIN
[2] HOP NECKER ENFANTS MALAD,F-75015 PARIS,FRANCE
来源：
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 1995年 / 33卷 / 11期
关键词：
SPARFLOXACIN; CIMETIDINE; PHARMACOKINETICS; DRUG INTERACTION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The interaction between cimetidine and sparfloxacin was studied in 10 healthy volunteers who received a single oral dose of 400 mg sparfloxacin on the third day of an 8 day cimetidine (400 mg t.i.d.) or placebo randomly assigned treatment. No statistically significant differences were observed in the pharmacokinetic parameters (C-max - AUC - T-1/2 - urinary excretion and metabolic ratio) of sparfloxacin following the 2 treatment. Cimetidine does not affect absorption, metabolism or urinary excretion of sparfloxacin; consequently, patients exposed to this drug combination are not at risk.
引用
收藏
页码：585 / 587
页数：3
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