THE ROLE OF SEROTONIN AND DOPAMINE IN BRAIN IN THE ANTIDEPRESSANT-LIKE EFFECT OF CLONIDINE IN THE FORCED SWIMMING TEST

被引：6

作者：

CERVO, L ^{[1
]}

ROSSI, C ^{[1
]}

SAMANIN, R ^{[1
]}

机构：

[1] MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62,I-20157 MILAN,ITALY

来源：

NEUROPHARMACOLOGY | 1992年 / 31卷 / 04期

关键词：

CLONIDINE; ANTIDEPRESSANT ACTIVITY; SEROTONIN; DOPAMINE; MESOLIMBIC SYSTEM; RAT;

D O I：

10.1016/0028-3908(92)90064-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of clonidine (0.1 mg/kg, i.p.), as a three-injection course, on behaviour in the forced swimming test was studied in rats injected intracerebroventricularly (i.c.v.) with 150-mu-g 5,7-dihydroxytryptamine (5,7-DHT) to destroy serotonin (5-HT) neurones or treated with 100 mg/kg (i.p.) (+/-)-sulpiride or 0.5-mu-g/0.5-mu-l (-)-sulpiride in the nucleus accumbens. Clonidine significantly increased struggling and reduced floating and the effects were antagonized by both treatments with sulpiride but not by 5,7-DHT which markedly depleted 5-HT in brain. The results suggest that the mesolimbic dopaminergic system but not 5-HT neurones, plays a permissive role in the antidepressant-like effect of clonidine in the forced swimming test.

引用

页码：331 / 335

页数：5

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