GOSSYPOL AND DERIVATIVES - A NEW CLASS OF ALDOSE REDUCTASE INHIBITORS

被引：47

作者：

DECK, LM ^{[1
]}

VANDERJAGT, DL ^{[1
]}

ROYER, RE ^{[1
]}

机构：

[1] UNIV NEW MEXICO,SCH MED,DEPT BIOCHEM,ALBUQUERQUE,NM 87131

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 11期

关键词：

D O I：

10.1021/jm00115a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta. Gossypol and a number of the derivatives were potent inhibitors. The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site. The structural but not the electronic aspects of the model were found to apply to this series of compounds.

引用

页码：3301 / 3305

页数：5

共 50 条

[21] An Efficient Synthesis of Quinoxalinone Derivatives as Potent Inhibitors of Aldose Reductase
Yang, Yanchun
Zhang, Shuzhen
Wu, Bobin
Ma, Mingming
Chen, Xin
Qin, Xiangyu
He, Minlan
Hussain, Saghir
Jing, Chaojun
Ma, Bing
Zhu, Changjin
CHEMMEDCHEM, 2012, 7 (05) : 823 - 835
[22] Pyridothiadiazine derivatives as aldose reductase inhibitors having antioxidant activity
Zhu, Shaojuan
Zhang, Shuzhen
Hao, Xin
Qin, Xiangyu
Parveen, Shagufta
Yang, Shaoqi
Ma, Bing
Zhu, Changjin
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2016, 31 : 126 - 130
[23] SYNTHESIS OF 3-AMINORHODANINE DERIVATIVES AS ALDOSE REDUCTASE INHIBITORS
HANEFELD, W
SCHLITZER, M
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 32 (03) : 1019 - 1025
[24] Synthesis of 3-Aminorhodanine Derivatives as Aldose Reductase Inhibitors
1995, (32)
[25] SPIROFLUORENEISOTHIAZOLIDINONE DIOXIDES - NEW ALDOSE AND ALDEHYDE REDUCTASE INHIBITORS
DUPRIEST, MT
KUZMICH, D
GRIFFIN, BW
MCNATT, LG
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 197 : 21 - MEDI
[26] NEW APPROACHES FOR TREATMENT IN DIABETES - ALDOSE REDUCTASE INHIBITORS
HOTTA, N
BIOMEDICINE & PHARMACOTHERAPY, 1995, 49 (05) : 232 - 243
[27] ALDOSE REDUCTASE INHIBITORS - A POTENTIAL NEW CLASS OF AGENTS FOR THE PHARMACOLOGICAL CONTROL OF CERTAIN DIABETIC COMPLICATIONS
KADOR, PF
KINOSHITA, JH
SHARPLESS, NE
JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (07) : 841 - 849
[28] Quantitative structure-activity relationship studies of a new class of selective aldose reductase inhibitors
Sharma, R.
Sahoo, P. K.
Chaturvedi, S. C.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2008, 47 (06): : 957 - 962
[29] ALDOSE REDUCTASE INHIBITORS AND CATARACT
CRABBE, MJC
INTERNATIONAL OPHTHALMOLOGY, 1991, 15 (01) : 25 - 36
[30] ALDOSE REDUCTASE INHIBITORS - AN UPDATE
TSAI, SC
BURNAKIS, TG
ANNALS OF PHARMACOTHERAPY, 1993, 27 (06) : 751 - 754

← 1 2 3 4 5 →