ESTABLISHMENT OF MULTIDRUG RESISTANT HUMAN COLORECTAL-CARCINOMA HCT-15 CELL-LINES AND THEIR PROPERTIES

被引：0
|
作者：
IWAHASHI, T
OKOCHI, E
ONO, K
SUGAWARA, I
TSURUO, T
MORI, S
机构：
[1] SAITAMA MED SCH, SAITAMA MED CTR, DEPT PATHOL, KAWAGOE, SAITAMA 350, JAPAN
[2] UNIV TOKYO, INST MED SCI, DEPT PATHOL, MINATO KU, TOKYO 108, JAPAN
[3] UNIV TOKYO, INST APPL MICROBIOL, BUNKYO KU, TOKYO 113, JAPAN
来源：
ANTICANCER RESEARCH | 1991年 / 11卷 / 03期
关键词：
MULTIDRUG RESISTANCE; SOLID TUMOR; P-GLYCOPROTEIN; VERAPAMIL; MRK16;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A series of MDR cell lines with various levels of P-glycoprotein have been established from a human colorectal carcinoma cell line, HCT-15, by stepwise exposure to adriamycin. The relative drug resistance of these cell lines correlated directly with both MDR1 mRNA levels and P-glycoprotein expression levels. Intracellular accumulation of adriamycin decreased inversely to their resistance. Drug sensitivities of these lines were reversed using verapamil. Since these cell lines are transplantable to nude mice, they may provide a useful animal model of MDR solid tumors for therapeutic experiments.
引用
收藏
页码：1309 / 1312
页数：4
相关论文
共 50 条
  • [41] PATTERN OF GROWTH-FACTOR, PROTOONCOGENE AND CARCINOEMBRYONIC ANTIGEN GENE-EXPRESSION IN HUMAN COLORECTAL-CARCINOMA CELL-LINES
    LAROCCA, RV
    PARK, JG
    DANESI, R
    DELTACCA, M
    STEINBERG, SM
    GAZDAR, AF
    ONCOLOGY, 1992, 49 (03) : 209 - 214
  • [42] CHARACTERIZATION OF THE MULTIPLE-DRUG RESISTANCE PHENOTYPE OF SEVERAL HUMAN COLORECTAL-CARCINOMA CELL-LINES SELECTED WITH VINCA ALKALOIDS
    DEHERDT, SV
    ANDREWS, EL
    MARDER, P
    MOORE, RE
    HOSKINS, J
    BUMOL, TF
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1988, 29 : 357 - 357
  • [43] DNA MISMATCH BINDING DEFECTS, DNA-DAMAGE TOLERANCE, AND MUTATOR PHENOTYPES IN HUMAN COLORECTAL-CARCINOMA CELL-LINES
    BRANCH, P
    HAMPSON, R
    KARRAN, P
    CANCER RESEARCH, 1995, 55 (11) : 2304 - 2309
  • [44] EXPRESSION OF A HUMAN MULTIDRUG RESISTANCE GENE IN HUMAN OVARIAN-CARCINOMA CELL-LINES
    SEKIYA, S
    NUNOYAMA, T
    SHIRASAWA, H
    KIMURA, H
    KAWATA, M
    IIJIMA, N
    SUGIMOTO, Y
    TSURUO, T
    TAKAMIZAWA, H
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 1992, 251 (02) : 79 - 86
  • [45] HUMAN RENAL-CELL CARCINOMA - ESTABLISHMENT AND CHARACTERIZATION OF 2 NEW CELL-LINES
    NAITO, S
    KANAMORI, T
    HISANO, S
    TANAKA, K
    MOMOSE, S
    KAMATA, N
    JOURNAL OF UROLOGY, 1982, 128 (05): : 1117 - 1121
  • [46] HUMAN SQUAMOUS-CELL CARCINOMA - ESTABLISHMENT AND CHARACTERIZATION OF NEW PERMANENT CELL-LINES
    KRAUSE, CJ
    CAREY, TE
    OTT, RW
    HURBIS, C
    MCCLATCHEY, KD
    REGEZI, JA
    ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 1981, 107 (11) : 703 - 710
  • [47] Cytotoxic Effect of Luteolin on Human Colorectal Cancer Cell Line (HCT-15): Crucial Involvement of Reactive Oxygen Species
    Pandurangan, Ashok Kumar
    Ganapasam, Sudhandiran
    MIDDLE EAST JOURNAL OF CANCER, 2013, 4 (04) : 175 - 180
  • [48] ESTABLISHMENT AND IN-VIVO CHARACTERIZATION OF MULTIDRUG-RESISTANT DUNNING R3327 RAT PROSTATE-CARCINOMA CELL-LINES
    BASHIR, I
    SIKORA, K
    ABEL, P
    FOSTER, CS
    INTERNATIONAL JOURNAL OF CANCER, 1994, 57 (05) : 719 - 726
  • [49] ESTABLISHMENT AND CHARACTERIZATION OF HUMAN MESOTHELIOMA CELL-LINES
    STJERNBERG, N
    LUNDGREN, E
    ROOS, G
    SINNA, GA
    EUROPEAN JOURNAL OF RESPIRATORY DISEASES, 1982, 63 : 45 - 45
  • [50] ESTABLISHMENT OF 5 HUMAN MYELOMA CELL-LINES
    NAMBA, M
    OHTSUKI, T
    MORI, M
    TOGAWA, A
    WADA, H
    SUGIHARA, T
    YAWATA, Y
    KIMOTO, T
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY, 1989, 25 (08): : 723 - 729
12345