ESTABLISHMENT OF MULTIDRUG RESISTANT HUMAN COLORECTAL-CARCINOMA HCT-15 CELL-LINES AND THEIR PROPERTIES

被引：0
|
作者：
IWAHASHI, T
OKOCHI, E
ONO, K
SUGAWARA, I
TSURUO, T
MORI, S
机构：
[1] SAITAMA MED SCH, SAITAMA MED CTR, DEPT PATHOL, KAWAGOE, SAITAMA 350, JAPAN
[2] UNIV TOKYO, INST MED SCI, DEPT PATHOL, MINATO KU, TOKYO 108, JAPAN
[3] UNIV TOKYO, INST APPL MICROBIOL, BUNKYO KU, TOKYO 113, JAPAN
来源：
ANTICANCER RESEARCH | 1991年 / 11卷 / 03期
关键词：
MULTIDRUG RESISTANCE; SOLID TUMOR; P-GLYCOPROTEIN; VERAPAMIL; MRK16;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A series of MDR cell lines with various levels of P-glycoprotein have been established from a human colorectal carcinoma cell line, HCT-15, by stepwise exposure to adriamycin. The relative drug resistance of these cell lines correlated directly with both MDR1 mRNA levels and P-glycoprotein expression levels. Intracellular accumulation of adriamycin decreased inversely to their resistance. Drug sensitivities of these lines were reversed using verapamil. Since these cell lines are transplantable to nude mice, they may provide a useful animal model of MDR solid tumors for therapeutic experiments.
引用
收藏
页码：1309 / 1312
页数：4
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