ACYCLOVIR-INDUCED ACUTE TUBULOINTERSTITIAL NEPHRITIS

被引：20
|
作者：
RASHED, A
AZADEH, B
ABUROMEH, SH
机构：
[1] HAMAD GEN HOSP,DEPT MED,DOHA,QATAR
[2] HAMAD GEN HOSP,DEPT PATHOL,DOHA,QATAR
来源：
NEPHRON | 1990年 / 56卷 / 04期
关键词：
Acute renal failure; Acyclovir; Granuloma; Interstitial nephritis; Tubular necrosis;
D O I：
10.1159/000186190
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Two patients with presumed herpes simplex encephalitis developed severe non-oliguric acute renal failure shortly after acyclovir infusions. Renal function returned to normal in less than 3 weeks after discontinuation of acylovir. Renal biopsies done during the acute phase demonstrated interstitial oedema, eosinophils and cellular aggregates in both and granulomata in the second case suggesting acyclovir-induced hypersensitivity interstitial nephritis.
引用
收藏
页码：436 / 438
页数：3
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