SYNTHESIS OF NEW GUANIDINE DERIVATIVES FROM 2',3',4',9'-TETRAHYDROSPIRO[PIPERIDINE-4,1'-[1H]PYRIDO[3,4-B]INDOLE]

被引：1

作者：

DOMANY, G

GIZUR, T

BARTASZALAI, G

SCHON, I

SZANTAY, C

HEGEDUS, B

机构：

[1] GEDEON RICHTER CHEM WORKS LTD,CHEM WORKS,SPECTROSCOP RES LAB,H-1475 BUDAPEST 10,HUNGARY

[2] GEDEON RICHTER CHEM WORKS LTD,CHEM WORKS,KISFALUDY LAJOS RES LAB,H-1475 BUDAPEST 10,HUNGARY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 06期

关键词：

D O I：

10.1002/jhet.5570310664

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of the isothiourea derivative 2 with mcthylaminc or pyrrolidine resulted in guanidines 3a-3b. Using hydrazine under the same conditions the tetrazole derivative 4 was obtained. On reacting 2 with piperidine, morpholine, methylhydrazine, phenylhydrazine, hydroxylamine or sodium hydroxide, cyclization took place leading to the novel 4-cyanimino-1,2,3,4,6,7,12, 12b-octahydro-3,12b-ethanopyrimido[1',6':1,2]pyrido[3,4-b]indole (5). Some structural aspects of 5 and other model compounds were analysed mainly by C-13 nmr spectroscopy.

引用

页码：1657 / 1660

页数：4

共 50 条

[21] 2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLES .2. REVERSIBLE TRANSFORMATION OF 1-ALKYL-2-(4,9-DIHYDRO-3H-PYRIDO[3,4-B]INDOL-1-YL)CYCLOHEXANOL INTO 1-ALKYLIDENE-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLES
BOBOWSKI, G
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1987, 24 (02) : 473 - 479
[22] STUDIES ON INDOLE DERIVATIVES .I. SYNTHESIS OF 3-PHENYL-9H-PYRIDAZINO(3,4-B)INDOLE DERIVATIVES
KOBAYASHI, G
FURUKAWA, S
CHEMICAL & PHARMACEUTICAL BULLETIN, 1964, 12 (10) : 1129 - +
[23] Design, synthesis and biological evaluation of novel 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole triazole derivatives as potent TRPV1 antagonists
Li, Jinyu
Nie, Cunbin
Qiao, Yue
Hu, Jing
Li, Qifei
Wang, Qiang
Pu, Xiaohui
Yan, Lin
Qian, Hai
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 178 : 433 - 445
[24] Design, synthesis, and evaluation of pyrido.[3,4-b]pyrazin-2(1H)-one derivatives as potent FLT3 inhibitors
Sun, Mei
Wang, Chang
Wang, Peipei
Ye, Qingqing
Zhou, Yubo
Li, Jia
Liu, Tao
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 79
[25] DESIGN AND SYNTHESIS OF SUBSTITUTED 1,2,3,4-TETRAHYDRO-9H-PYRIDO (3, 4-B) INDOLE-2-SULPHONYL DERIVATIVES AS POTENTIAL ANTITHROMBOTIC AGENTS
Khan, Imran A.
Gaur, Stuti
Pandey, Suresh K.
Pal, Yogendra
Dixit, Madhu
Saxena, Anil K.
MEDICINAL CHEMISTRY RESEARCH, 2010, 19 : S70 - S71
[26] Design, Synthesis, and Biological Evaluation of 1-(thiophen-2-yl)-9H-pyrido[3,4-b]indole Derivatives as Anti-HIV-1 Agents
Ashok, Penta
Lu, Cui-Lin
Chander, Subhash
Zheng, Yong-Tang
Murugesan, Sankarnarayanan
CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 85 (06) : 722 - 728
[27] UNUSUAL FORMATION OF A NOVEL PYRROLO[1',2'/1,2]PYRIDO[3,4-B]INDOLE
GIRI, VS
DAS, SK
SANKAR, PJ
SHOOLERY, JN
KEIFER, P
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1992, 29 (04) : 767 - 769
[28] 9-SUBSTITUTED 4,9-DIHYDROPYRANO[3,4-B]INDOL-1(3H)-ONES - SYNTHESIS AND CONVERSION INTO 2,3,4,9-TETRAHYDRO-1H-PYRIDO-[3,4-B]INDOLES .4.
ELGENDY, AA
LEHMANN, J
ARCHIV DER PHARMAZIE, 1987, 320 (08) : 698 - 704
[29] Synthesis of new 1H-pyrazolo[3,4-b]pyridine derivatives
Bernardino, AMR
Romeiro, GA
Mello, H
deSouza, MCBV
Ferreira, VF
HETEROCYCLIC COMMUNICATIONS, 1996, 2 (05) : 415 - 416
[30] ANTIPARASITIC AGENTS .8. SYNTHESIS OF 1,6-DISUBSTITUTED-9H-PYRIDO[3,4-B]INDOLES AND 1,8-DISUBSTITUTED-9H-PYRIDO[3,4-B]INDOLES AND 2-SUBSTITUTED-1(3),10-DIHYDRO-9-PHENYLPYRIDO-[3,4-B]IMIDAZO[4,5-G]INDOLES AND THEIR ANTHELMINTIC ACTIVITY
AGARWAL, A
AGARWAL, SK
BHAKUNI, DS
GUPTA, S
KATIYAR, JC
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1989, 28 (11): : 943 - 949

← 1 2 3 4 5 →