MATURATION OF CD4-8- ALPHA/BETA TCR+ T-CELLS INDUCED BY CD2-STIMULATION INVIVO AND INVITRO

被引：14
|
作者：
TIEFENTHALER, G [1 ]
HANKE, T [1 ]
HUNIG, T [1 ]
机构：
[1] INST VIROL & IMMUNOBIOL,VERSBACHER STR 7,W-8700 WURZBURG,GERMANY
来源：
INTERNATIONAL IMMUNOLOGY | 1992年 / 4卷 / 07期
关键词：
T-CELL DIFFERENTIATION; CD2; DN T-CELLS;
D O I：
10.1093/intimm/4.7.825
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Newly generated ('virgin') rat thymocytes of the immature CD4+8+ double positive (DP) subset were treated in suspension culture for 2 days with the stimulatory pair of anti-CD2 monoclonal antibodies OX-54 and OX-55. Approximately 50% of the recovered cells had downregulated CD4 and CD8 and upregulated the T cell antigen receptor (TCR). CD2-stimulated, but not control thymocytes proliferated in response to TCR plus IL-2 stimulation. In vivo, postnatal injection of OX-54/55 led to a dramatic and selective increase in functionally mature CD4-CD8- double negative (DN) alpha/beta - TCR(high) thymocytes and peripheral T cells. These findings show that CD2 stimulation can promote T cell differentiation and suggest that DN TCR(high) thymocytes can be generated from DP thymocytes via alternative pathways of T cell maturation.
引用
收藏
页码：825 / 829
页数：5
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