Antiplatelet antibody may cause delayed transfusion-related acute lung injury

被引：1

作者：

Torii, Yoshitaro ^{[1
]}

Shimizu, Toshiki ^{[1
]}

Yokoi, Takashi ^{[1
]}

Sugimoto, Hiroyuki ^{[1
]}

Katashiba, Yuichi ^{[1
]}

Ozasa, Ryotaro ^{[1
]}

Fujita, Shinya ^{[1
]}

Adachi, Yasushi ^{[2
]}

Maki, Masahiko ^{[1
]}

Nomura, Shosaku ^{[1
]}

机构：

[1] Kansai Med Univ, Dept Internal Med 1, Osaka, Japan

[2] Toyooka Hosp, Dept Clin Pathol, Hyogo, Japan

来源：

INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2011年 / 4卷

关键词：

delayed TRALI syndrome; recurrence; anti-platelet antibody;

D O I：

10.2147/IJGM.S23220

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 61-year-old woman with lung cancer developed delayed transfusion-related acute lung injury (TRALI) syndrome after transfusion of plasma- and leukoreduced red blood cells (RBCs) for gastrointestinal bleeding due to intestinal metastasis. Acute lung injury (ALI) recurred 31 days after the first ALI episode. Both ALI episodes occurred 48 hours after transfusion. Laboratory examinations revealed the presence of various antileukocyte antibodies including antiplatelet antibody in the recipient's serum but not in the donors' serum. The authors speculate that antiplatelet antibodies can have an inhibitory effect in the recipient, which can modulate the bona fide procedure of ALI and lead to a delay in the onset of ALI. This case illustrates the crucial role of a recipient's platelets in the development of TRALI.

引用

页码：677 / 680

页数：4

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