CLONING AND SEQUENCE-ANALYSIS OF A MURINE CDNA-ENCODING GLUTAMATE-DECARBOXYLASE (GAD65)

被引：36
|
作者：
LEE, DS [1 ]
TIAN, JD [1 ]
PHAN, T [1 ]
KAUFMAN, DL [1 ]
机构：
[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT PSYCHIAT & BIOBEHAV SCI,760 WESTWOOD PLAZA,LOS ANGELES,CA 90024
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1216卷 / 01期
关键词：
GLUTAMATE DECARBOXYLASE; CDNA; CLONING; GAD; GABA; DIABETES; (NOD MOUSE);
D O I：
10.1016/0167-4781(93)90056-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report the cloning and cDNA sequence of murine GAD65. Murine GAD65 is comprised of 585 amino acids and shares a high degree of homology with human and rat GAD65, with most divergences occurring near their amino-termini. The murine GAD65 sequence will allow evaluation of the role of this gene in murine neurogenetic and autoimmune diseases.
引用
收藏
页码：157 / 160
页数：4
相关论文
共 50 条
  • [1] CLONING AND SEQUENCE-ANALYSIS OF A CDNA-ENCODING RAT PREPROCHOLECYSTOKININ
    DESCHENES, RJ
    LORENZ, LJ
    HAUN, RS
    ROOS, BA
    COLLIER, KJ
    DIXON, JE
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (03): : 726 - 730
  • [2] A SENSITIVE ELISA FOR QUANTITATIVE-DETERMINATION OF GLUTAMATE-DECARBOXYLASE (GAD65)
    SCHLOSSER, M
    HAHMANN, J
    AUGSTEIN, P
    ZIEGLER, B
    ZIEGLER, M
    DIABETOLOGIA, 1995, 38 : A6 - A6
  • [3] INDUCED TOLERANCE TO PEPTIDES OF GLUTAMATE-DECARBOXYLASE (GAD65) PREVENTS MURINE INSULIN-DEPENDENT DIABETES
    KAUFMAN, DL
    TIAN, J
    LEHMANN, PV
    FORSTHUBER, T
    NEWMAN, D
    ATKINSON, MA
    SERCARZ, EE
    TOBIN, AJ
    CLARESALZLER, M
    FASEB JOURNAL, 1994, 8 (05): : A978 - A978
  • [4] CLONING AND SEQUENCE-ANALYSIS OF THE CDNA-ENCODING A SNAKE NEUROTOXIN PRECURSOR
    TAMIYA, T
    LAMOUROUX, A
    JULIEN, JF
    GRIMA, B
    MALLET, J
    FROMAGEOT, P
    MENEZ, A
    TOXICON, 1985, 23 (04) : 613 - 613
  • [5] CLONING AND SEQUENCE-ANALYSIS OF THE CDNA-ENCODING A SNAKE NEUROTOXIN PRECURSOR
    TAMIYA, T
    LAMOUROUX, A
    JULIEN, JF
    GRIMA, B
    MALLET, J
    FROMAGEOT, P
    MENEZ, A
    BIOCHIMIE, 1985, 67 (02) : 185 - 189
  • [6] NUCLEOTIDE-SEQUENCE AND CHROMOSOMAL ASSIGNMENT OF A CDNA-ENCODING THE LARGE ISOFORM OF HUMAN GLUTAMATE-DECARBOXYLASE
    KELLY, CD
    EDWARDS, Y
    JOHNSTONE, AP
    HARFST, E
    NOGRADI, A
    NUSSEY, SS
    POVEY, S
    CARTER, ND
    ANNALS OF HUMAN GENETICS, 1992, 56 : 255 - 265
  • [7] CLONING AND SEQUENCE-ANALYSIS OF CDNA-ENCODING RHIZOPUS-NIVEUS LIPASE
    KUGIMIYA, W
    OTANI, Y
    KOHNO, M
    HASHIMOTO, Y
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1992, 56 (05) : 716 - 719
  • [8] MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF CDNA-ENCODING HUMAN FERROCHELATASE
    NAKAHASHI, Y
    TAKETANI, S
    OKUDA, M
    INOUE, K
    TOKUNAGA, R
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (02) : 748 - 755
  • [9] CLONING AND SEQUENCE-ANALYSIS OF CDNA-ENCODING UROTENSIN-I PRECURSOR
    ISHIDA, I
    ICHIKAWA, T
    DEGUCHI, T
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (02) : 308 - 312
  • [10] A ROLE FOR GLUTAMATE-DECARBOXYLASE DURING TOMATO RIPENING - THE CHARACTERIZATION OF A CDNA-ENCODING A PUTATIVE GLUTAMATE-DECARBOXYLASE WITH A CALMODULIN-BINDING SITE
    GALLEGO, PP
    WHOTTON, L
    PICTON, S
    GRIERSON, D
    GRAY, JE
    PLANT MOLECULAR BIOLOGY, 1995, 27 (06) : 1143 - 1151
12345