REGULATION OF IL-2 PRODUCTION BY MONONUCLEAR-CELLS FROM RHEUMATOID-ARTHRITIS SYNOVIAL-FLUIDS

被引：0
|
作者：
FLESCHER, E
BOWLIN, TL
TALAL, N
机构：
[1] AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284
[2] MARION MERRELL DOW RES INST,CINCINNATI,OH
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1992年 / 87卷 / 03期
关键词：
IL-2; RHEUMATOID ARTHRITIS; POLYAMINES;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Products of polyamine oxidation down-regulate IL-2 production by peripheral blood T cells. We show here that the production of IL-2 by rheumatoid arthritis synovial fluid mononuclear cells is inversely correlated with the concentrations of polyamines in these cells. In addition. the inhibition of polyamine biosynthesis or oxidation in cultures of these cells enhances their ability to produce IL-2. Our findings suggest that polyamine oxidation plays an important role in the suppression of T cell function characteristic of rheumatoid arthritis synovial fluids.
引用
收藏
页码：435 / 437
页数：3
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