EXPRESSION OF INTERLEUKIN-8 CORRELATES WITH THE METASTATIC POTENTIAL OF HUMAN-MELANOMA CELLS IN NUDE-MICE

被引：2

作者：

SINGH, RK ^{[1
]}

GUTMAN, M ^{[1
]}

RADINSKY, R ^{[1
]}

BUCANA, CD ^{[1
]}

FIDLER, IJ ^{[1
]}

机构：

[1] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT CELL BIOL, HOUSTON, TX 77030 USA

来源：

CANCER RESEARCH | 1994年 / 54卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We correlated the steady state transcription and protein secretion of interleukin 8 (IL-8) in 13 different human melanoma cell lines with their ability to grow and produce metastasis in nude mice. Highly metastatic cells expressed higher steady state levels of IL-8 mRNA transcripts than did low metastatic cells. In situ mRNA hybridization analyses confirmed the pattern of mRNA expression on a cellular level. Increased mRNA expression directly correlated with secretion of IL-8 protein as determined by enzyme-linked immunosorbent assay. Recombinant IL-8 stimulated the proliferation of low metastatic A375P cells in a dose-dependent manner, a stimulation that was abrogated by the use of a polyclonal antibody against IL-8. The data suggest that IL-8 can be an autocrine growth factor for human melanoma cells and that IL-8 is involved in melanoma metastasis.

引用

页码：3242 / 3247

页数：6

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