HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF PEPTIDES AT REDUCED TEMPERATURES - SEPARATION OF ISOMERS

被引：12
|
作者：
LEBL, M [1 ]
FANG, S [1 ]
HRUBY, VJ [1 ]
机构：
[1] UNIV ARIZONA,DEPT CHEM,TUCSON,AZ 85721
来源：
JOURNAL OF CHROMATOGRAPHY | 1991年 / 586卷 / 01期
关键词：
D O I：
10.1016/0021-9673(91)80032-C
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Cholecystokinin analogues containing N-methyl amino acids were studied by reversed-phase high-performance liquid chromatography at reduced temperatures. A reduction in temperature to -17-degrees-C led to lower efficiency, but at the same time separations of cis and trans isomers (and some impurities) were achieved. The velocity constants for cis-trans equilibria were calculated.
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页码：145 / 148
页数：4
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