ENDOTHELIN RECEPTORS IN CULTURED RENAL EPITHELIAL-CELLS

被引：25
|
作者：
NEUSER, D
ZAISS, S
STASCH, JP
机构：
[1] Institute of Pharmacology, Bayer AG, 5600 Wuppertal 1
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 02期
关键词：
Ca[!sup]2+[!/sup] (intracellular); Endothelin; LLC-PK[!sub]1[!/sub] cells; MDCK cells; Renal reabsorption;
D O I：
10.1016/0014-2999(90)90536-F
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We demonstrated the presence of specific binding sites for endothelin in the renal epithelial cell lines. MDCK and LLC-PK1. Endothelin binding induced mobilisation of intracellular calcium, as shown by an increase in 45Ca2+ efflux. This suggests a direct effect of endothelin on renal reabsorption in addition to the effects on the renal vasculature. © 1990.
引用
收藏
页码：241 / 243
页数：3
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