VARIATION IN THE EXPRESSION OF C-FOS AFTER INTOXICATION BY SOMAN - COMPARATIVE-STUDY USING INSITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY

被引：9
|
作者：
CHOLLATNAMY, A [1 ]
DELAMANCHE, IS [1 ]
BOUCHAUD, C [1 ]
机构：
[1] CTR ETUD BOUCHET, VERT LE PETIT, FRANCE
来源：
BRAIN RESEARCH | 1993年 / 603卷 / 01期
关键词：
FOS MESSENGER RNA; C-FOS; PROTEIN; CHOLINESTERASE INHIBITOR; GENE EXPRESSION; SEIZURE; RAT BRAIN;
D O I：
10.1016/0006-8993(93)91296-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A massive and transitory increase in c-fos mRNA and Fos protein occurred in rats intoxicated by a single dose of soman (organophosphate compound and irreversible cholinesterase inhibitor) only in animals that had seizures. Comparison of immunohistochemistry that localizes Fos protein and of in situ hybridization that localizes its mRNA showed that there was an early and explosive expression of mRNA in many cerebral regions followed by transitory immunoreactivity in only some regions (piriform cortex, entorhinal area, hippocampus). The levels of mRNA and c-fos-like immunoreactivity decreased slowly and returned to basal level 24 h after soman administration.
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页码：32 / 37
页数：6
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