Stem cells: general aspects, biological and molecular events

被引：0

作者：

Acevedo Toro, Paola Andrea ^{[1
]}

Cortes Marquez, Monica Maria ^{[2
,3
]}

机构：

[1] Univ Antioquia, Integrante Grp HEMO Hematopatol Mol, Hematol, Medellin, Colombia

[2] Univ Antioquia, Bacteriol Lab Clin, Medellin, Colombia

[3] Univ Antioquia, Escuela Microbiol, Hematol, Medellin, Colombia

来源：

IATREIA | 2008年 / 21卷 / 03期

关键词：

ARF-1; protein; BMI-1; gene; Differentiation; Microenviroment; NANOG gene; Notch receptors; OCT3/; 4; genes; p16(Ink4a) genes; Self-renewal; SOX2; Stem cells; Transcription factors; Wnt proteins;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Self-renewal capacity and differentiation are features of stem cells that vary among the different cellular types according to the tissue in which they reside and the surrounding microenvironment. Cellular cycle inhibitors, genes implied in chromosomal rearrangements, essential development proteins and specific signaling pathways intervene in these processes. Self-renewal is regulated by different mechanisms, the most important of which are the Wnt, Notch and Hedgehog pathways, and the factors BMI-1, p16(Ink4a), ARF, NANOG, OCT3/4, SOX2, HOXB4 and their paralogs. Advances in the knowledge of stem cells biology and of the molecular mechanisms that influence their self-renewal and differentiation have made these cells an important promise for both basic and applied research.

引用

页码：292 / 306

页数：15

共 50 条

[41] Molecular biological aspects of inhibitor development
Tuddenham, EGD
VOX SANGUINIS, 1999, 77 : 13 - 16
[42] MOLECULAR BIOLOGICAL ASPECTS OF ESTROGEN ACTION
RUBIN, BL
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1969, (SEP): : ME22 - &
[43] Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells
Ling, Ling
Camilleri, Emily T.
Helledie, Torben
Samsonraj, Rebekah M.
Titmarsh, Drew M.
Chua, Ren Jie
Dreesen, Oliver
Dombrowski, Christian
Rider, David A.
Galindo, Mario
Lee, Ian
Hong, Wanjin
Hui, James H.
Nurcombe, Victor
van Wijnen, Andre J.
Cool, Simon M.
GENE, 2016, 576 (01) : 292 - 303
[44] CELLULAR AND MOLECULAR ASPECTS OF EARLY EVENTS IN NEUROGENESIS
DUPRAT, AM
ARCHIVES D ANATOMIE MICROSCOPIQUE ET DE MORPHOLOGIE EXPERIMENTALE, 1986, 75 (03): : 178 - 178
[45] General requirements for stem cells
Hao, Jie
Ma, Aijin
Wang, Lei
Cao, Jiani
Chen, Si
Wang, Liu
Fu, Boqiang
Zhou, Jiaxi
Pei, Xuetao
Zhang, Yu
Xiang, Peng
Hu, Shijun
Li, Qiyuan
Zhang, Yong
Xia, Yingjie
Zhu, Huanxin
Stacey, Glyn
Zhou, Qi
Zhao, Tongbiao
CELL PROLIFERATION, 2020, 53 (12)
[46] Ethical and biological aspects concerning the use of human embryonic stem cells and the legal situation in Germany
Badura-Lotter, G
PLURIPOTENT STEM CELLS: THERAPEUTIC PERSPECTIVES AND ETHICAL ISSUES, 2001, : 55 - 61
[47] Biological Aspects and Clinical Applications of Mesenchymal Stem Cells: Key Features You Need to be Aware of
Saeedi, Mohammad
Nezhad, Muhammad Sadeqi
Mehranfar, Fatemeh
Golpour, Mahdieh
Esakandari, Mohammad Ali
Rashmeie, Zahra
Ghorbani, Maryam
Nasimi, Fatemeh
Hoseinian, Seyed Nasser
CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021, 22 (02) : 200 - 215
[48] Bioelectrochemistry based on molecular insight of biological events
Aizawa, M
ELECTROCHEMISTRY, 2000, 68 (11) : 846 - 846
[49] CELLULAR AND MOLECULAR BIOLOGICAL EVENTS AT THE IMPLANT INTERFACE
BAGAMBISA, FB
KAPPERT, HF
SCHILLI, W
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 1994, 22 (01): : 12 - 17
[50] Neural stem and progenitor cells in developing neocortex-Molecular, cellular and evolutionary aspects
Huttner, Wieland B.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2012, 30 (08) : 629 - 629

← 1 2 3 4 5 →