STUDIES ON AGENTS WITH VASODILATOR AND BETA-BLOCKING ACTIVITIES .2.

被引：0
|
作者：
SEKI, T
TAKEZAKI, T
OHUCHI, R
OHUYABU, H
TANIMOTO, Y
YAMAGUCHI, T
SAITOH, M
ISHIMORI, T
YASUDA, K
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1995年 / 43卷 / 02期
关键词：
PHENOXYPROPANOLAMINE; HYDRAZINOPYRIDAZINE; ANTIHYPERTENSIVE AGENT; HYPOTENSIVE ACTIVITY; BETA-BLOCKING ACTIVITY; BETA(1)-SELECTIVITY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of phenoxypropanolamines having a hydrazinopyridazinyl moiety was synthesized. Their hypotensive and beta-blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Some of them exhibited both activities. In particular, compound 20k is a candidate for clinical use due to its hypotensive activity, equal to that of hydralazine, and its beta-blocking activity, 2.7-fold more potent than that of propranolol.
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页码：247 / 255
页数：9
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