BIOCHEMICAL-CHARACTERIZATION OF PLASMODIUM-FALCIPARUM HEMOZOIN
被引:60
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作者:
GOLDIE, P
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机构:MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DIV HEMATOL,BRONX,NY 10467
GOLDIE, P
ROTH, EF
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机构:MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DIV HEMATOL,BRONX,NY 10467
ROTH, EF
OPPENHEIM, J
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机构:MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DIV HEMATOL,BRONX,NY 10467
OPPENHEIM, J
VANDERBERG, JP
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机构:MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DIV HEMATOL,BRONX,NY 10467
VANDERBERG, JP
机构:
[1] MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DIV HEMATOL,BRONX,NY 10467
[2] NYU MED CTR,DEPT MED & MOLEC PARASITOL,NEW YORK,NY 10016
[3] NYU MED CTR,DEPT MICROBIOL,NEW YORK,NY 10016
来源:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
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1990年
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43卷
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06期
关键词:
D O I:
10.4269/ajtmh.1990.43.584
中图分类号:
R1 [预防医学、卫生学];
学科分类号:
1004 ;
120402 ;
摘要:
Hemozoin, the pigment granule which develops within the blood stage food vacuole of the malaria parasite Plasmodium falciparum, was biochemically characterized. Hemozoin was found to be composed of 65% protein, 16% ferriprotoporphyrin-IX (hematin), 6% carbohydrate, and trace amounts of lipid and nucleic acids. The overwhelming majority of the protein component is a mixture of native and denatured human globin non-covalently associated with the metalloporphyrin. Immunoelectron microscopy, employing anti-human hemoglobin as a probe, identified in situ association of hemoglobin with hemozoin. Hemozoin produced within diabetic blood had a higher proportion of carbohydrate, suggesting that the carbohydrate component comes from non-enzymatic glycosylation of hemoglobin.
机构:
UNIV CALIF SAN FRANCISCO, DEPT PHARMACEUT CHEM, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT PHARMACEUT CHEM, SAN FRANCISCO, CA 94143 USA
ROSENTHAL, PJ
NELSON, RG
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机构:
UNIV CALIF SAN FRANCISCO, DEPT PHARMACEUT CHEM, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT PHARMACEUT CHEM, SAN FRANCISCO, CA 94143 USA