SYNTHESIS OF 2-DIMETHYLAMINOIMIDAZOLE DERIVATIVES - A NEW ACCESS TO INDOLYL-IMIDAZOLE ALKALOIDS OF MARINE ORIGIN

被引：29

作者：

DALKAFOUKI, A ^{[1
]}

ARDISSON, J ^{[1
]}

KUNESCH, N ^{[1
]}

LACOMBE, L ^{[1
]}

POISSON, JE ^{[1
]}

机构：

[1] COLL FRANCE,CNRS,CHIM INTERACT MOLEC LAB,F-75231 PARIS 05,FRANCE

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 39期

关键词：

INDOLYL-IMIDAZOLES; ALKALOIDS; APLYSINOPSIN; 2-DIMETHYLAMINOIMIDAZOLE; MARINE PRODUCTS;

D O I：

10.1016/S0040-4039(00)92376-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first preparation of 2-dimethylaminoimidazole 1a, a structural feature of several marine products was undertaken and its reactivity investigated. The synthesis of natural alkaloids 5 and 12b was achieved by direct coupling of the easily accessible oxidized 2-dimethylaminoimidazoles 7 and 8 with indole-3-carboxaldehyde and indole respectively, demonstrating the usefulness of this approach for other structurally related natural products.

引用

页码：5325 / 5328

页数：4

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