The State of the Antioxidant System during Therapy of Patients with Multiple Sclerosis

被引：4

作者：

Smirnova, L. P. ^{[1
]}

Krotenko, N. V. ^{[2
]}

Grishko, E. V. ^{[2
]}

Krotenko, N. M. ^{[2
]}

Alifirova, V. M. ^{[2
]}

Ivanova, S. A. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Mental Hlth Res Inst Tomsk, Ul Aleutskaya 4,V Sosnovy Bor, Tomsk 634014, Russia

[2] Siberian State Med Univ, Tomsk, Russia

来源：

BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY | 2011年 / 5卷 / 01期

关键词：

oxidative stress; antioxidant enzymes; multiple sclerosis;

D O I：

10.1134/S1990750811010136

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activity of erythrocyte glutathione peroxidase (GPx), glutathione reductase (GR), glutathione transferase (GT), glucose-6-phosphate dehydrogenase (G6PDH), catalase and superoxide dismutase (SOD), the level of erythrocyte malonic dialdehyde (MDA) and also total antioxidant activity of blood serum were studied in patients with different types of multiple sclerosis (MS). Investigation of peripherical blood was carried out on the first day of admission to the hospital and after the standard therapy with copaxone. During the whole period of observation all MS patients had a high level of MDA and activity of erythrocyte GP com pared with a control group. Other erythrocyte antioxidant enzymes and total antioxidant activity of blood serum exhibited weak positive dynamics in patients with relapsing-remitting multiple sclerosis (RRMS). The pathological decrease of antioxidant system activity in patients with secondary progressive multiple sclerosis (SPMS) was more pronounced and remained unchanged after the treatment. This is consistent with a more severe clinical course of this disease.

引用

页码：76 / 80

页数：5

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