PASTEURELLA-MULTOCIDA TOXIN INDUCES IL-6, BUT NOT IL-1-ALPHA OR TNF-ALPHA IN FIBROBLASTS

被引：0
|
作者：
ROSENDAL, S
FRANDSEN, PL
NIELSEN, JP
GALLILY, R
机构：
[1] NATL VET LAB,DK-1790 COPENHAGEN,DENMARK
[2] HEBREW UNIV JERUSALEM,LAUTENBERG CTR GEN & TUMOR IMMUNOL,IL-91010 JERUSALEM,ISRAEL
来源：
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE | 1995年 / 59卷 / 02期
关键词：
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Pasteurella multocida toxin (PMT) is the major virulence factor in Progressive Atrophic Rhinitis of swine. Other workers' previous findings that PMT was mitogenic for 3T3 fibroblasts, were confirmed in the present study. In addition, PMT stimulated 3T3 cells to release IL-6, but IL-1 alpha or TNF alpha were not detected in fibroblast supernatants sampled 24, 48, or 72 h after stimulation. In view of the role of IL-6 in osteoclastic bone resorption, these findings provide a new working hypothesis for investigations into the molecular pathogenesis of this important disease.
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页码：154 / 156
页数：3
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