NUCLEOTIDE-SEQUENCE THE ESCHERICHIA-COLI K12 HISTIDINE OPERON REVISITED

被引：4

作者：

JOVANOVIC, G ^{[1
]}

KOSTIC, T ^{[1
]}

JANKOVIC, M ^{[1
]}

SAVIC, DJ ^{[1
]}

机构：

[1] INST MOLEC GENET & GENET ENGN, YU-11001 BELGRADE, YUGOSLAVIA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1994年 / 239卷 / 03期

关键词：

ESCHERICHIA COLI K-12; HISTIDINE OPERON; NUCLEOTIDE SEQUENCE; POLYMORPHISM; POLA1 AND MUTD5 MUTATORS;

D O I：

10.1006/jmbi.1994.1384

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report on a significant difference between the published nucleotide sequence of the Escherichia coli K12 histidine operon and our sequencing results repeatedly obtained from a number of different E. coli K12 strains. The discrepancies include 39 base-pair changes and one addition located predominantly in the proximal portion of the operon. Our data also suggest that neutral and near-neutral mutations do not accumulate to a significant extent in the histidine operon of E. coli strains harbouring strong mutator alleles.

引用

页码：433 / 435

页数：3

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