NEUROFIBRILLARY TANGLES IN DEMENTIA-PUGILISTICA ARE UBIQUITINATED

被引：56
|
作者：
DALE, GE
LEIGH, PN
LUTHERT, P
ANDERTON, BH
ROBERTS, GW
机构：
[1] ST MARYS HOSP, SCH MED, DEPT ANAT & CELL BIOL, PRAED ST, LONDON W2 1PG, ENGLAND
[2] ST GEORGE HOSP, SCH MED, DEPT IMMUNOL, LONDON, ENGLAND
[3] INST PSYCHIAT, COLL NEUROL, LONDON SE5 8AF, ENGLAND
[4] INST PSYCHIAT, DEPT NEUROPATHOL, LONDON SE5 8AF, ENGLAND
[5] INST PSYCHIAT, DEPT NEUROSCI, LONDON SE5 8AF, ENGLAND
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1991年 / 54卷 / 02期
关键词：
D O I：
10.1136/jnnp.54.2.116
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Ubiquitin, a protein thought to be involved in the ATP-dependent nonlysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.
引用
收藏
页码：116 / 118
页数：3
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