Nuclear hormone receptors PXR and CAR and metabolic diseases

被引：9
|
作者：
Mo, Li [3 ]
He, Jinhan [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Pharm, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Geriatr, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
来源：
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION | 2014年 / 19卷 / 02期
基金：
美国国家科学基金会;
关键词：
constitutive androstane receptor (CAR); metabolic diseases; nuclear receptors; pregnane X receptor (PXR);
D O I：
10.1515/hmbci-2014-0006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nuclear receptors (NRs) belong to a superfamily of evolutionarily related DNA-binding transcription factors that can be activated by steroid and thyroid hormones, and other lipid metabolites. Ligand activated NRs can regulate target gene expression by binding to DNA response elements present in the target gene promoters. Through this regulation, NRs are broadly implicated in physiology and metabolism. In this chapter, we will focus on the xenobiotic receptors and their recently discovered functions in metabolic diseases.
引用
收藏
页码：129 / 140
页数：12
相关论文
共 50 条
  • [31] Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis
    Yoshinari, Kouichi
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2019, 42 (08) : 1243 - 1252
  • [32] Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes
    Kandel, Benjamin A.
    Thomas, Maria
    Winter, Stefan
    Damm, Georg
    Seehofer, Daniel
    Burk, Oliver
    Schwab, Matthias
    Zanger, Ulrich M.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2016, 1859 (09): : 1218 - 1227
  • [33] 3D structures and ligand specificities of nuclear xenobiotic receptors CAR, PXR and VDR
    Wu, Baojian
    Li, Sha
    Dong, Dong
    DRUG DISCOVERY TODAY, 2013, 18 (11-12) : 574 - 581
  • [34] Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR
    Handschin, C
    Meyer, UA
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2005, 433 (02) : 387 - 396
  • [35] Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
    Bwayi, Monicah N.
    Garcia-Maldonado, Efren
    Chai, Sergio C.
    Xie, Boer
    Chodankar, Shirish
    Huber, Andrew D.
    Wu, Jing
    Annu, Kavya
    Wright, William C.
    Lee, Hyeong-Min
    Seetharaman, Jayaraman
    Wang, Jingheng
    Buchman, Cameron D.
    Peng, Junmin
    Chen, Taosheng
    NUCLEIC ACIDS RESEARCH, 2022, 50 (06) : 3254 - 3275
  • [36] Xenobiotic-Sensing Nuclear Receptors CAR and PXR as Drug Targets in Cholestatic Liver Disease
    Kakizaki, Satoru
    Takizawa, Daichi
    Tojima, Hiroki
    Yamazaki, Yuichi
    Mori, Masatomo
    CURRENT DRUG TARGETS, 2009, 10 (11) : 1156 - 1163
  • [37] Contribution of the nuclear receptors PXR and CAR to gene expression modulations induced by fipronil in rodent liver
    Roques, B.
    Lacroix, M. Z.
    Moussaoui, N.
    Leghait, J.
    Puel, S.
    Lasserre, F.
    Guillou, H.
    Vigiue, C.
    Martin, P. G. P.
    JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2012, 35 : 43 - 44
  • [38] PXR and CAR: Nuclear receptors which play a pivotal role in drug disposition and chemical toxicity
    Stanley, Lesley A.
    Horsburgh, Brian C.
    Ross, Jillian
    Scheer, Nico
    Wolf, C. Roland
    DRUG METABOLISM REVIEWS, 2006, 38 (03) : 515 - 597
  • [39] The xenobiotic receptors PXR and CAR in liver physiology, an update
    Cai, Xinran
    Young, Gregory M.
    Xie, Wen
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2021, 1867 (06):
  • [40] A brief history of the discovery of PXR and CAR as xenobiotic receptors
    Jiong Yan
    Wen Xie
    Acta Pharmaceutica Sinica B, 2016, 6 (05) : 450 - 452
12345