Nuclear hormone receptors PXR and CAR and metabolic diseases

被引：9
|
作者：
Mo, Li [3 ]
He, Jinhan [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Pharm, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Geriatr, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
来源：
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION | 2014年 / 19卷 / 02期
基金：
美国国家科学基金会;
关键词：
constitutive androstane receptor (CAR); metabolic diseases; nuclear receptors; pregnane X receptor (PXR);
D O I：
10.1515/hmbci-2014-0006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nuclear receptors (NRs) belong to a superfamily of evolutionarily related DNA-binding transcription factors that can be activated by steroid and thyroid hormones, and other lipid metabolites. Ligand activated NRs can regulate target gene expression by binding to DNA response elements present in the target gene promoters. Through this regulation, NRs are broadly implicated in physiology and metabolism. In this chapter, we will focus on the xenobiotic receptors and their recently discovered functions in metabolic diseases.
引用
收藏
页码：129 / 140
页数：12
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