CHARACTERIZATION OF AN ACUTE T-LYMPHOBLASTIC LEUKEMIA EXPRESSING THE GAMMA/DELTA-T-CELL RECEPTOR

被引：6
|
作者：
WILHELM, M
TONY, HP
机构：
[1] Medizinische Poliklinik, University of Würzburg, Würzburg, W-8700
来源：
BLUT | 1990年 / 61卷 / 04期
关键词：
γ/δ receptor; T-cell leukemia;
D O I：
10.1007/BF01744133
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Leukemic cells of a 20 year old patient, suffering from acute lymphoblastic leukemia, were characterized by surface marker and functional analysis. A significant cell population within this type of leukemia expresses concomitantly the CD4 and CD8 antigen on the same cell and might represent a new differentiation stage of T-cells with the γ/δ receptor. The leukemic cells show a distinct pattern of growth response to mitogens and lymphokines, which might correlate to their differentiation stage. Moreover, a "natural killer"-like activity can be induced in these cells by IL-2. © 1990 Springer-Verlag.
引用
收藏
页码：213 / 218
页数：6
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