SENSITIVE ASSAY FOR COCAINE AND BENZOYLECGONINE USING SOLID-PHASE EXTRACTION AND GAS-CHROMATOGRAPHY

被引：10
|
作者：
VIRAG, L [1 ]
JAMDAR, S [1 ]
CHAO, CR [1 ]
MORISHIMA, HO [1 ]
机构：
[1] COLUMBIA UNIV, COLL PHYS & SURG, DEPT OBSTET & GYNECOL, NEW YORK, NY 10032 USA
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 1994年 / 658卷 / 01期
关键词：
D O I：
10.1016/0378-4347(94)00198-7
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
An improved method for the simultaneous determination of cocaine and benzoylecgonine by means of gas chromatography with nitrogen-phosphorus detection is described. Following a solid-phase extraction and derivatization of benzoylecgonine to its butyl ester, chromatography was performed using a capillary column. The n-propylester of benzoylecgonine served as the internal standard. The assay was linear from 4 to 2000 ng/ml for both cocaine and benzoylecgonine, with a good precision over this concentration range. This method may be particularly useful for small volume samples since it requires only 250 mu l of plasma for analysis of both cocaine and benzoylecgonine.
引用
收藏
页码：135 / 141
页数：7
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