SYNTHESIS OF (+/-)-CYCLOHEXANE-1(R),2(R),4(R)-TRIOL-TRIPHOSPHATE, A DEOXYGENATED ANALOG OF MYO-INOSITOL-1,4,5-TRIPHOSPHATE

被引：10

作者：

SCHMITT, L ^{[1
]}

SPIESS, B ^{[1
]}

SCHLEWER, G ^{[1
]}

机构：

[1] CNRS, CTR NEUROCHIM, PHARMACOCHIM MOLEC LAB, 5 RUE BLAISE PASCAL, F-67084 STRASBOURG, FRANCE

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 15期

关键词：

D O I：

10.1016/0040-4039(92)88127-Q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

For the use in the studies of inositol-phosphates, (+/-) cyclohexane-1(R), 2(R), 4(R)-triol-triphosphate 2 was synthesized from anisole. The synthesis used 1,2-benzenedimethanol as a ketone and phosphate protective group which induced easy cristallization of the intermediates. Regeneration of the free ketone 9 under mild conditions followed by its selective reduction and phosphorylation by the phosphite method gave the expected compound 2.

引用

页码：2013 / 2016

页数：4

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