ONE-POT PREPARATION OF 3-METHYLENEPYRROLIDINES WITH HIGH DIASTEREOMERIC EXCESS

被引:11
|
作者
VANDERHEIDE, TAJ [1 ]
VANDERBAAN, JL [1 ]
DEKIMPE, V [1 ]
BICKELHAUPT, F [1 ]
KLUMPP, GW [1 ]
机构
[1] FREE UNIV AMSTERDAM,SCHEIKUNDIG LAB,DE BOELELAAN 1083,1081 HV AMSTERDAM,NETHERLANDS
关键词
BIFUNCTIONAL ANNULATION REAGENT; ALLYLZINC COMPOUNDS; PD(0)-CATALYSIS; PROLINE; HETEROCYCLIC RING SYNTHESIS;
D O I
10.1016/S0040-4039(00)73690-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Addition of allylzinc reagents 1 to imines carrying a carbalkoxy group at C-alpha or C-alpha', followed by Pd(0)-catalyzed cyclization permits the one-pot preparation of 3-methylenepyrrolidines with high diastereoselectivity.
引用
收藏
页码:3309 / 3310
页数:2
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