INCREASED LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AND INTERLEUKIN-1-BETA (IL-1-BETA) IN TRACHEAL ASPIRATES OF NEWBORNS WITH PNEUMONIA

被引：15
|
作者：
BUCK, C [1 ]
GALLATI, H [1 ]
POHLANDT, F [1 ]
BARTMANN, P [1 ]
机构：
[1] F HOFFMANN LA ROCHE & CO LTD,PHARMACEUT RES NEW TECHNOL,CH-4002 BASEL,SWITZERLAND
来源：
INFECTION | 1994年 / 22卷 / 04期
关键词：
D O I：
10.1007/BF01739905
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Pneumonia is one of the major sites of infection in ventilated newborns. We investigated whether the cytokines IL-1 beta and TNF-alpha are detectable in tracheal aspirates of newborns with pneumonia as a diagnostic marker. All 12 infants with pneumonia had elevated levels of IL-1 beta (range 30-300 pg/ml) and TNF-alpha (range 60-680 pg/ml), whereas control infants (n=21; respiratory distress syndrome, very low birth weight or infants intubated preoperatively) had no detectable levels of IL-1 beta or TNF-alpha. In vitro investigations with mononuclear cells of umbilical cord blood were performed to rule out that exogenously added surfactant influences IL-1 beta and TNF-alpha production. It is concluded that IL-1 beta and TNF-alpha are important and specific mediators of neonatal pneumonia which may be of diagnostic importance.
引用
收藏
页码：238 / 241
页数：4
相关论文
共 50 条
  • [41] PNEUMOLYSIN STIMULATES PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA BY HUMAN MONONUCLEAR PHAGOCYTES
    HOULDSWORTH, S
    ANDREW, PW
    MITCHELL, TJ
    INFECTION AND IMMUNITY, 1994, 62 (04) : 1501 - 1503
  • [42] INDUCTION OF SUPPURATIVE ARTHRITIS IN RABBITS BY HAEMOPHILUS ENDOTOXIN, TUMOR-NECROSIS-FACTOR-ALPHA, AND INTERLEUKIN-1-BETA
    SAEZLLORENS, X
    JAFARI, HS
    OLSEN, KD
    NARIUCHI, H
    HANSEN, EJ
    MCCRACKEN, GH
    JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (06): : 1267 - 1272
  • [43] INTERLEUKIN-1-BETA AND TUMOR-NECROSIS-FACTOR-ALPHA RELEASE IN NORMAL AND DISEASED HUMAN INFRARENAL AORTAS
    PEARCE, WH
    SWEIS, I
    YAO, JST
    MCCARTHY, WJ
    KOCH, AE
    JOURNAL OF VASCULAR SURGERY, 1992, 16 (05) : 784 - 789
  • [44] THE INVOLVEMENT OF INTERLEUKIN-1 (IL-1) AND TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) IN THE RESPONSE TO DNA-DAMAGE
    MOREB, J
    STOBER, C
    SAFAH, H
    BLOOD, 1993, 82 (10) : A529 - A529
  • [45] MECHANISMS OF STIMULATION OF INTERLEUKIN-1-BETA AND TUMOR-NECROSIS-FACTOR-ALPHA BY MYCOBACTERIUM-TUBERCULOSIS COMPONENTS
    ZHANG, YH
    DOERFLER, M
    LEE, TC
    GUILLEMIN, B
    ROM, WN
    JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (05): : 2076 - 2083
  • [46] EFFECT OF XANTHINE DERIVATES AND DEXAMETHASONE ON STREPTOCOCCUS PNEUMONIAE-STIMULATED PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-1-BETA (IL-1-BETA), AND IL-10 BY HUMAN-LEUKOCYTES
    VANFURTH, AM
    SEIJMONSBERGEN, EM
    LANGERMANS, JAM
    VANDERMEIDE, PH
    VANFURTH, R
    CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1995, 2 (06) : 689 - 692
  • [47] INCREASED SECRETION OF TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-1-BETA, AND INTERLEUKIN-6 BY ALVEOLAR MACROPHAGES FROM PATIENTS WITH SARCOIDOSIS
    STEFFEN, M
    PETERSEN, J
    OLDIGS, M
    KARMEIER, A
    MAGNUSSEN, H
    THIELE, HG
    RAEDLER, A
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1993, 91 (04) : 939 - 949
  • [48] SERUM LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-1 ALPHA AND BETA IN HEALTHY ELDERLY SUBJECTS
    MOORADIAN, AD
    REED, RL
    SCUDERI, P
    AGE, 1991, 14 (03) : 61 - 64
  • [49] INTERLEUKIN-2 (IL-2) STIMULATES THE PRODUCTION OF INTERLEUKIN 1-BETA (IL 1-BETA), INTERLEUKIN-1-ALPHA (IL-1-ALPHA), AND TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) FROM HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS (PBMC)
    NUMEROF, RP
    DINARELLO, CA
    ENDRES, S
    LONNEMANN, G
    VANDERMEER, JWM
    MIER, JW
    IMMUNOBIOLOGY, 1987, 175 (1-2) : 117 - 117
  • [50] TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AND HEMATOPOIESIS
    KOEFFLER, HP
    TOBLER, A
    RANYARD, J
    JOHNSON, D
    MUNKER, R
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 184 - 184
12345