Inflammatory myofibroblastic tumor of the urinary bladder diagnosed by anaplastic lymphoma kinase immunostaining

被引：14
|
作者：
Rao, Ram Nawal [1 ]
Ranjan, Priydarshi [2 ]
Singla, Nidhi [1 ]
Pandey, Rakesh [1 ]
机构：
[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Pathol, Raibarely Rd, Lucknow, Uttar Pradesh, India
[2] Sanjay Gandhi Postgrad Inst Med Sci, Dept Urol, Lucknow, Uttar Pradesh, India
来源：
UROLOGY ANNALS | 2012年 / 4卷 / 02期
关键词：
Anaplastic lymphoma kinase-1; inflammatory myofibroblastic tumor; sarcomatoid urothelial carcinoma; urinary bladder;
D O I：
10.4103/0974-7796.95567
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Inflammatory myofibroblastic tumor (IMFT) of the urinary bladder is an unusual spindle cell lesion that exhibits cytologic atypia, infiltrative growth, and mitotic activity mimicking malignant tumors, such as leiomyosarcoma, rhabdomyosarcoma, and sarcomatoid carcinoma. Recently, anaplastic lymphoma kinase (ALK) gene translocations or ALK protein expression in IMFT has been reported, especially in patients of children and young adults. This lesion has been described in numerous locations in addition to the urinary bladder. The detection of ALK protein and ALK gene rearrangements are useful in distinguishing IMFT from spindle cell malignancies in the urinary bladder.
引用
收藏
页码：115 / 118
页数：4
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