MOLECULAR-CLONING OF CDNA-ENCODING THE 110-KDA AND 21-KDA REGULATORY SUBUNITS OF SMOOTH-MUSCLE PROTEIN PHOSPHATASE-1M

被引：124
|
作者：
CHEN, YH
CHEN, MX
ALESSI, DR
CAMPBELL, DG
SHANAHAN, C
COHEN, P
COHEN, PTW
机构：
[1] UNIV DUNDEE,DEPT BIOCHEM,MRC,PROT PHOSPHORYLAT UNIT,DUNDEE DD1 4HN,SCOTLAND
[2] ADDENBROOKES HOSP,DEPT MED,CAMBRIDGE,ENGLAND
来源：
FEBS LETTERS | 1994年 / 356卷 / 01期
关键词：
SMOOTH MUSCLE; PROTEIN PHOSPHATASE; CDNA SEQUENCE; MYOSIN; ANKYRIN REPEAT; LEUCINE ZIPPER;
D O I：
10.1016/0014-5793(94)01231-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structures of the M(110) and M(21) regulatory subunits of protein phosphatase-1M, the major enzyme which dephosphorylates myosin in smooth muscle, have been deduced from cloned cDNAs. The N-terminus of the M(110) subunit from rat aorta contains seven ankyrin repeats, while the C-terminus of the M(21) subunit from chicken gizzard contains a leucine zipper motif. The M(110) subunit is expressed in two different forms which differ in their C-terminal sequences. One of these is highly homologous to the whole of the M(21) subunit.
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页码：51 / 55
页数：5
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