STIMULATION AND INHIBITION OF INTERFERON-BETA PRODUCTION OF HUMAN-DIPLOID FIBROBLASTS BY FOODSTUFFS

被引：18

作者：

YAMADA, K ^{[1
]}

MATSUMURA, K ^{[1
]}

SUZAKI, M ^{[1
]}

SHIRAHATA, S ^{[1
]}

MURAKAMI, H ^{[1
]}

机构：

[1] KYUSHU UNIV 4609,FAC AGR,DEPT FOOD SCI & TECHNOL,6-10-1 HAKOZAKI,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1991年 / 55卷 / 03期

关键词：

D O I：

10.1080/00021369.1991.10870664

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

We screened for foodstuffs affecting interferon-beta (IFN-beta) production of human foreskin diploid fibroblasts, in the presence of poly I.poly C, cycloheximide, and actinomycin D. alpha- and beta-caseins stimulated IFN-beta production dose-dependently, but kappa-casein inhibited it. Of the two chymosin fragments of kappa-casein, glycomacropeptide was an inhibitor but p-kappa-casein was not. beta-lactoglobulin stimulated IFN-beta production weakly, but lactoferrin inhibited it strongly. It was also shown that serum contained some factors inhibiting IFN-beta induction and stimulating its production.

引用

页码：829 / 832

页数：4

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