SYNTHESIS AND X-RAY CRYSTAL-STRUCTURE OF 2-ACETYL-9-AZABICYCLO[4.2.1]NONAN-3-ONE - A CONFORMATIONALLY LOCKED S-CIS ANALOG OF ANATOXIN-A

被引：6

作者：

BROUGH, PA

GALLAGHER, T

THOMAS, P

WONNACOTT, S

BAKER, R

MALIK, KMA

HURSTHOUSE, MB

机构：

[1] UNIV BATH, SCH CHEM, BATH BA2 7AY, AVON, ENGLAND

[2] UNIV BATH, SCH BIOL SCI, BATH BA2 7AY, AVON, ENGLAND

[3] MERCK SHARP & DOHME LTD, CTR NEUROSCI RES, HARLOW CM20 2QR, ENGLAND

[4] UNIV WALES COLL CARDIFF, COLL CARDIFF, SCH CHEM & APPL CHEM, CARDIFF CF1 3TB, WALES

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 15期

关键词：

D O I：

10.1039/c39920001087

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Acetyl-9-azabicyclo[4.2.1.]nonan-3-one 2 ('hydroxyanatoxin-a'), which represents a conformationally locked variant of the s-cis conformer of the potent cholinergic agonist anatoxin-a, is synthesised and characterised; this molecule lacks both nicotinic and muscarinic potency.

引用

页码：1087 / 1089

页数：3

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