The impact of peroxisomes on cellular aging and death

被引：32
|
作者：
Manivannan, Selvambigai [1 ]
Scheckhuber, Christian Quintus [1 ]
Veenhuis, Marten [1 ]
van der Klei, Ida Johanna [1 ]
机构：
[1] Univ Groningen, Kluyver Ctr Genom Ind Fermentat, Groningen Biomol Sci & Biotechnol Inst, Mol Cell Biol, Nijenborgh 7, NL-9747 AG Groningen, Netherlands
来源：
FRONTIERS IN ONCOLOGY | 2012年 / 2卷
关键词：
aging; autophagy; cell death; peroxisome; yeast;
D O I：
10.3389/fonc.2012.00050
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Peroxisomes are ubiquitous eukaryotic organelles, which perform a plethora of functions including hydrogen peroxide metabolism and 13-oxidation of fatty acids. Reactive oxygen species produced by peroxisomes are a major contributing factor to cellular oxidative stress, which is supposed to significantly accelerate aging and cell death according to the free radical theory of aging. However, relative to mitochondria, the role of the other oxidative organelles, the peroxisomes, in these degenerative pathways has not been extensively investigated. In this contribution we discuss our current knowledge on the role of peroxisomes in aging and cell death, with focus on studies performed in yeast.
引用
收藏
页码：1 / 7
页数：7
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