INFLUENCE OF NMDA RECEPTOR LIGANDS ON THYROTROPIN-RELEASING HORMONE-INDUCED SCRATCHING IN RABBITS

被引：1
|
作者：
POPOLI, P
CAPORALI, MG
DECAROLIS, AS
机构：
[1] Pharmacology Department, Istituto Superiore di Sanità, 00161 Rome
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 272卷 / 01期
关键词：
NMDA (N-METHYL-D-ASPARTATE); TRH (THYROTROPIN-RELEASING HORMONE); DOPAMINE; STRIATUM; (RABBIT);
D O I：
10.1016/0014-2999(94)00701-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The influence of intracaudate administration of N-methyl-D-aspartic acid (NMDA) and of the competitive NMDA receptor antagonist, DL-2-amino-5-phosphonovaleric acid (AP-5) was studied on thyrotropin-releasing hormone (TRH)-induced scratching in rabbits. NMDA (28 nmol) significantly increased the latency of TRH-induced scratching but did not modify the duration of this behaviour. Conversely, AP-5 (0.5 mu mol) significantly potentiated scratching duration. Since TRH-induced scratching has been reported to be a dopamine-dependent behaviour, these results suggest that NMDA receptor ligands modulate dopaminergic neurotransmission.
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页码：119 / 121
页数：3
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