INFLUENCE OF NMDA RECEPTOR LIGANDS ON THYROTROPIN-RELEASING HORMONE-INDUCED SCRATCHING IN RABBITS

被引：1
|
作者：
POPOLI, P
CAPORALI, MG
DECAROLIS, AS
机构：
[1] Pharmacology Department, Istituto Superiore di Sanità, 00161 Rome
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 272卷 / 01期
关键词：
NMDA (N-METHYL-D-ASPARTATE); TRH (THYROTROPIN-RELEASING HORMONE); DOPAMINE; STRIATUM; (RABBIT);
D O I：
10.1016/0014-2999(94)00701-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The influence of intracaudate administration of N-methyl-D-aspartic acid (NMDA) and of the competitive NMDA receptor antagonist, DL-2-amino-5-phosphonovaleric acid (AP-5) was studied on thyrotropin-releasing hormone (TRH)-induced scratching in rabbits. NMDA (28 nmol) significantly increased the latency of TRH-induced scratching but did not modify the duration of this behaviour. Conversely, AP-5 (0.5 mu mol) significantly potentiated scratching duration. Since TRH-induced scratching has been reported to be a dopamine-dependent behaviour, these results suggest that NMDA receptor ligands modulate dopaminergic neurotransmission.
引用
收藏
页码：119 / 121
页数：3
相关论文
共 50 条
  • [1] EFFECTS OF SCH-23390 ON THYROTROPIN-RELEASING HORMONE-INDUCED BEHAVIOR IN RABBITS
    POPOLI, P
    CAPORALI, MG
    DECAROLIS, AS
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 173 (2-3) : 211 - 213
  • [2] STUDIES ON THYROTROPIN-RELEASING HORMONE-INDUCED MICTURITION IN CATS
    BELESLIN, DB
    JOVANOVICMICIC, D
    SAMARDZIC, R
    TERZIC, B
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 1987, 39 (06) : 474 - 476
  • [3] THYROTROPIN-RELEASING HORMONE-INDUCED CONTRACTION OF URETHRAL AND VAGINAL MUSCLE
    ZACUR, HA
    GENADRY, R
    ROCK, JA
    KING, TM
    SMITH, BR
    FOSTER, GV
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 61 (04): : 787 - 789
  • [4] EFFECTS OF TRIIODOTHYRONINE ON THYROTROPIN-RELEASING HORMONE-INDUCED THYROTROPIN RELEASE IN THE NEONATAL RAT
    WALKER, P
    COULOMBE, P
    DUSSAULT, JH
    ENDOCRINOLOGY, 1980, 107 (06) : 1731 - 1737
  • [5] Thyrotropin-releasing hormone-induced growth hormone secretion in dogs with primary hypothyroidism
    Diaz-Espineira, M. M.
    Galac, S.
    Mol, J. A.
    Rijnberk, A.
    Kooistra, H. S.
    DOMESTIC ANIMAL ENDOCRINOLOGY, 2008, 34 (02) : 176 - 181
  • [6] THYROTROPIN-RELEASING HORMONE-INDUCED MYOCLONUS AND TREMOR IN A PATIENT WITH HASHIMOTOS ENCEPHALOPATHY
    ISHII, K
    HAYASHI, A
    TAMAOKA, A
    USUKI, S
    MIZUSAWA, H
    SHOJI, S
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1995, 310 (05): : 202 - 205
  • [7] THE EFFECT OF DOPAMINE ON THYROTROPIN-RELEASING HORMONE-INDUCED PROLACTIN SECRETION INVITRO
    FAGIN, KD
    NEILL, JD
    ENDOCRINOLOGY, 1981, 109 (06) : 1835 - 1840
  • [8] THYROTROPIN-RELEASING HORMONE-STIMULATED INOSITOL TRISPHOSPHATE FORMATION IS LIABLE TO THYROTROPIN-RELEASING HORMONE-INDUCED DESENSITIZATION BY A CALCIUM-DEPENDENT MECHANISM
    TORJESEN, PA
    BJORO, T
    OSTBERG, BC
    HAUG, E
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1988, 56 (1-2) : 107 - 114
  • [9] Effects of hypothalamic dopamine on growth hormone-releasing hormone-induced growth hormone secretion and thyrotropin-releasing hormone-induced prolactin secretion in goats
    Jin, Jin
    Hashizume, Tsutomu
    ANIMAL SCIENCE JOURNAL, 2015, 86 (06) : 634 - 640
  • [10] GATA2 Mediates the Thyrotropin-Releasing Hormone-Induced Transcriptional Activation of the Thyrotropin β Gene
    Ohba, K.
    Sasaki, S.
    Matsushita, A.
    Iwaki, H.
    Matsunaga, H.
    Suzuki, S.
    Misawa, H.
    Nakamura, H.
    ENDOCRINE REVIEWS, 2010, 31 (03) : S2544 - S2544
12345