DIODE-ARRAY DETECTION OF LOW-LEVEL CO-ELUTING SPECIES IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：4
|
作者：
ANDERSON, NH
GRAY, MR
HINDS, CJ
机构：
[1] Sterling Research Group, Alnwick, Northumberland NE66 2JH, Willowburn Avenue
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1990年 / 8卷 / 8-12期
关键词：
CHROMATOGRAPHIC PEAK INTEGRITY ASSESSMENT; DIODE ARRAY SPECTROSCOPY; HPLC; ANTAZOLINE; DANAZOL; CO-ELUTING SPECIES;
D O I：
10.1016/0731-7085(90)80132-9
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple and sensitive method for detecting low levels (0.5 and 1.0%, w/w) of co-eluting species in HPLC has been developed. This method is based on the subtraction of normalized peak up-slope and down-slope spectra from that of the apex. Visual inspection of the resultant "difference spectra" allows for a qualitative judgement regarding the integrity of the peak under consideration.
引用
收藏
页码：853 / 857
页数：5
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