DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer

被引：0
|
作者：
Board, Ruth E. [1 ]
Knight, Lucy [2 ]
Greystoke, Alastair [1 ]
Blackhall, Fiona H. [3 ]
Hughes, Andrew [4 ]
Dive, Caroline [5 ]
Ranson, Malcolm [6 ]
机构：
[1] Paterson Inst Canc Res, Clin & Expt Pharmacol, Wilmslow Rd, Manchester M20 4BX, Lancs, England
[2] AstraZeneca, Discovery Med, Macclesfield SK10 4TG, Cheshire, England
[3] Christie Hosp NHS Trust, CRUK Dept Med Oncol, Manchester M20 4BX, Lancs, England
[4] AstraZeneca, Discovery Med, Macclesfield SK10 4TG, Cheshire, England
[5] Paterson Inst Canc Res, Clin & Expt Pharmacol, Manchester M20 4BX, Lancs, England
[6] Christie Hosp NHS Trust, CRUK Dept Med Oncol, Manchester M20 4BX, Lancs, England
来源：
BIOMARKER INSIGHTS | 2007年 / 2卷
关键词：
DNA methylation; biomarker; circulating tumour DNA; MSP; MethyLight;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Free circulating DNA, which is thought to be derived from the primary tumour, can be detected in the blood of patients with cancer. Detection of genetic and epigenetic alteration in this tumour DNA offers a potential source of development of prognostic and predictive biomarkers for cancer. One such change is DNA methylation of the promotor region of tumour suppressor genes. This causes down regulation of tumour suppressor gene expression, a frequent event in carcinogenesis. Hypermethylation of the promotor region of a number of genes has been detected in many tumour types and more recently these changes have been detected in circulating tumour DNA. This review will summarise the literature detailing DNA methylation in circulating tumour DNA and discuss some of the current controversies and technical challenges facing its use as a potential biomarker for cancer.
引用
收藏
页码：307 / 319
页数：13
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