SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF A NEW CLASS OF 2-OXO-8-AZASPIRO (4,5)DECAN-1-ONES AS ANALOGS OF THE MUSCARINIC AGONIST RS-86

被引：0

作者：

CIGNARELLA, G ^{[1
]}

VILLA, S ^{[1
]}

BARLOCCO, D ^{[1
]}

机构：

[1] UNIV MODENA,DIPARTIMENTO SCI FARMACEUT,I-41100 MODENA,ITALY

来源：

FARMACO | 1993年 / 48卷 / 10期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new series of 8-substituted-2-oxo-8-azapsiro (4,5)decan-1-ones has been synthesized and compounds tested for their cholinergic properties in comparison with the muscarinic agonist RS-86. Preliminary in vitro and in vivo pharmacological data indicate that none of them is provided with significant cholinergic effects either at central or peripheral level. A possible explanation for the lack of activity is given on the basis of conformational studies.

引用

页码：1439 / 1445

页数：7

共 32 条

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