SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF A NEW CLASS OF 2-OXO-8-AZASPIRO (4,5)DECAN-1-ONES AS ANALOGS OF THE MUSCARINIC AGONIST RS-86

被引：0
|
作者：
CIGNARELLA, G [1 ]
VILLA, S [1 ]
BARLOCCO, D [1 ]
机构：
[1] UNIV MODENA,DIPARTIMENTO SCI FARMACEUT,I-41100 MODENA,ITALY
来源：
FARMACO | 1993年 / 48卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new series of 8-substituted-2-oxo-8-azapsiro (4,5)decan-1-ones has been synthesized and compounds tested for their cholinergic properties in comparison with the muscarinic agonist RS-86. Preliminary in vitro and in vivo pharmacological data indicate that none of them is provided with significant cholinergic effects either at central or peripheral level. A possible explanation for the lack of activity is given on the basis of conformational studies.
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页码：1439 / 1445
页数：7
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