RELATIONSHIP BETWEEN GENETIC-FACTORS AND IMMUNE-RESPONSE IN PSORIASIS PATIENTS

Tissue typing of HLA system A, B, C locuses was carried out with the lymphocyte toxic method developed by Terasaki and McLelland in 296 psoriasis patients, 197 of them Uzbeks. In 65 psoriasis patients (Uzbeks) cellular and humoral immunity parameters were examined. Elevated detection rate of HLA system antigens A1, A11, B13, B17, B21, Cw3 was revealed in psoriasis patients both Uzbeks and representatives of other nationalities. The Uzbek and non-Uzbek patients with psoriasis differed in respect of HLA-A19 and HLA-B14 antigens. A relationship between immunogenetic factors and immune response manifectation has been revealed in psoriasis patients: a marked deficit of T lymphocytes, T helpers, T suppressors, and immunoregulatory subpopulation ratio index are observed in the presence of HLA B13, Cw3, B17 antigens; IgA immunodeficiency is also associated with these antigens.